Conformationally rigid pyrazoloquinazoline α-amino acids: one- and two-photon induced fluorescence

Conformationally rigid aromatic amino acids as potential building blocks for abiotic foldamers.

This communication describes the development of conformationally constrained unnatural aromatic amino acids, constructed on rigid backbone wherein the carboxyl and amino groups project in two dimensions (planes) on the aromatic framework. Such a feature offers the possibility of design and development of conformationally ordered synthetic oligomers with intriguing structural architectures disti...

Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides.

The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni(II) Schiff base complex as the key step.

One-pot Sequence for the Decarboxylation of a-Amino Acids One-pot Sequence for the Decarboxylation of α-Amino Acids

Synlett 2003, No. 4, Print: 12 03 2003. Art Id.1437-2096,E;2003,0,04,0542,0546,ftx,en;D28903ST.pdf. © Georg Thieme Verlag Stuttgart · New York ISSN 0936-5214 Abstract: Treatment of an α-amino acid with N-bromosuccinimide in water at pH 5 or in an alcoholic-aqueous ammonium chloride mixture, followed by addition of nickel(II) chloride and sodium borohydride, effected an overall decarboxylation v...

Molecular photobleaching kinetics of Rhodamine 6G by one- and two-photon induced confocal fluorescence microscopy.

Under high-excitation irradiance conditions in one- and two-photon induced fluorescence microscopy, the photostability of fluorescent dyes is of crucial importance for the detection sensitivity of single molecules and for the contrast in fluorescence imaging. Herein, we report on the dependence of photobleaching on the excitation conditions, using the dye Rhodamine 6G as a typical example. The ...

Two-photon Fluorescence Endomicroscopy